A randomized controlled trial (ClinicalTrials.gov Identifier: NCT04639752) was conducted in which women were randomized 1:1 to control and intervention groups. The aim of this study was to assess, in a real-world setting, the effectiveness and acceptability of remote peer support intervention for women experiencing mental distress early after delivery. In addition, the study aimed to uncover the adaptations needed for widescale implementation across the Czech Republic.

In the Czech Republic, there were 89,084 live births in 2023 (Národní zdravotnický informační portál [NZIP, 2023]). The vast majority of births take place in maternity hospitals. Planned home births are not formally integrated into the public healthcare system. Official statistics on the number of home births are not systematically collected. However, research and expert estimates suggest that home births remain rare in the Czech Republic (Krepelka et al., 2023; Vintrová & Pařízek, 2018). Obstetric care, including prenatal check-ups and delivery, is covered by public health insurance. The Czech Society of Neonatology recommends discharging mothers and newborns from the hospital 72 hours after delivery in cases of uncomplicated births (Mydlilova, 2013). In contrast to countries like the United States or the United Kingdom, the Czech Republic lacks a structured, nationwide system of perinatal mental health care (Horakova et al., 2024). In practice, support is typically provided by individual professionals from general psychiatry or psychology. Women who require psychotropic medication must consult a psychiatrist in person, as prescriptions cannot be issued without a face-to-face appointment. The first routine gynecological check-up following childbirth usually takes place around six weeks postpartum. There is currently no standardized mental health screening protocol for the perinatal period, although the Edinburgh Postnatal Depression Scale (EPDS) is utilized in some maternity hospitals and gynecology clinics.

Participants were recruited from May 2021 to April 2023 in five maternity hospitals across three regions of the Czech Republic. Participants were informed about the study by a nurse or midwife in the maternity unit. The recruitment criteria included women aged 18-45 years who spoke Czech, had an email address, had given birth in a hospital, and scored ≥ 10 on the Edinburgh Postnatal Depression Scale (EPDS). These women were then invited to participate in the study. The cutoff score 10 on the EPDS was used to identify women who show symptoms of depression. Based on an analysis of the available evidence, the authors describe that women who score more than 10 on the EPDS may already be signaling the presence of distress and depressive symptoms, and omitting them from population-based interventions could lead to the under-detection of women and their families who deserve intervention so that their psychological state does not deteriorate further (Khanlari et al., 2019). Women with an EPDS score < 10 were sent an automated email thanking them for their interest in the study and informing them that they were at a low risk for postpartum distress; these women were not included in the trial. After obtaining informed consent, a nurse or midwife provided the woman with a tablet containing online questionnaires on the second day after delivery. To maintain the usual clinical workflow, the recruitment and study procedures were integrated into the classical clinical workflow of the maternity wards. Teams in the participating maternity hospitals received a small financial remuneration from the study budget of 60,000 Czech crowns per year (2,640 USD per year per team). Women with a score of ³ 10 on the Edinburgh Postnatal Depression Scale (EPDS) were invited to participate in the study. The system did not provide the maternity hospital staff with information regarding the participants’ scores.

After completing informed consent and baseline questionnaires, women with an EPDS ≥ 10 were randomized 1:1 to control and intervention groups. All women received an information email with the results of their EPDS screening. Women in the intervention group were informed that they were at higher risk of psychological distress based on the screening results and that a peer consultant would contact them within the next 2-3 days (see the Intervention section for more details). The control group was also informed of their higher risk based on the screening results but was provided with mental health care information and resources instead.

Each participant received an email invitation to complete a follow-up questionnaire six weeks after their enrollment. If a participant did not complete the follow-up questionnaire, an automated reminder was sent three times over the next three days. Participants were not financially or otherwise motivated to complete a follow-up questionnaire. Participants who completed the questionnaire later than seven weeks after delivery were excluded from the analysis due to a non-matching follow-up time.

This study was performed in line with the principles of the Declaration of Helsinki. Approval was granted by the Ethics Committee of National Institute of Mental Health (2020). Informed consent to participate was obtained from all individual participants included in the study.

In this study, we implemented the Mom Supports Mom intervention to provide peer support for women experiencing postpartum mental health challenges. A peer consultant contacted participants assigned to the intervention group within three days of completing the questionnaires. The peer consultant contacted the participant by phone, text message, and email up to three times or until the participant responded to the offer of support. Each reciprocal interaction, i.e., a contact from the consultant and a response from the participant, was counted as one contact with the peer consultant. If there was no reciprocal contact, we labeled the intervention as an unrealized peer contact, and these participitants were removed from the analyses. The conversation between the participant and the peer consultant ended when the woman stated that she had no problems to discuss, felt fine, or was not interested in further conversations. In this case, the peer consultant reassured the woman that she could seek support at any time in the future and sent her a text message or email with contact information for seeking help if needed. If the woman at risk stated that she was not feeling well and agreed to continue the conversation, the peer consultant proceeded to help her identify the difficulties she was experiencing. The peer consultant helped participants to cope with mild symptoms related to common maternity problems directly (through listening, emotional release, relaxation techniques, etc.). For moderate to severe symptoms that interfered with the woman’s normal functioning (e.g., suicidal thoughts, sleep disturbances, deteriorating mental state), the peer consultant would refer the woman to professional medical or psychological help. The main indicator of whether the peer counsellors should consider the symptoms as mild or more severe was whether the difficulties described by the woman affected her daily functioning. If the woman was interested, contact with the peer consultant could be repeated; the frequency and form of further consultations would depend on mutual agreement. We designed the Mom Supports Mom intervention, which follows the mental health screening in maternity hospital, in line with the WHO recommendations described in the Guide for Integration of Perinatal Mental Health in Maternal and Child Health Services (World Health Organization, 2022). Further information on the methodology of the Mom Supports Mom intervention is described in the Appendix.

The peer team consisted of ten consultants and was further divided into two regional teams. The regional team consisted of one senior peer consulant (coordinator and team intervisor) and four peer consultants. Before the onset of the trial, all peers participated in an initial eight-hour in person-training session. The training covered the following areas: the psyche of women in the perinatal period and an overview of psychological difficulties, methods and principles of peer support, basics of crisis communication and psychological first aid, basics of psychotherapy, and basics of mental hygiene for peer consultants (Curry et al. 2019; Mulvale et al. 2019; Prevatt et al. 2018). At the end of the training, the peer consultant took a test to verify the knowledge acquired. Training was conducted by psychiatrists, psychologists, and senior peer consultants from the Centre of Perinatal Mental Health at National Institute of Mental Health, Klecany, Czechia, as well as representatives from the patient non-govermental organization Mom’s Smile. Further, each peer consultant was supervised and intervised once a month, either by sharing among other peer consultants in the regional team (intervision) or under the guidance of a psychologist, psychotherapist, or psychiatrist (supervision). In addition to the regular monthly interviews and supervision, peers could request additional sessions as needed. Intervisions and supervisions took place via video communication channels. The cost per regional peer team was 108,000 Czech crowns ($4, 680) per year and was covered by the study budget.

Primary outcome was the change in depressive symptoms between delivery and the sixth week after delivery, comparing the experimental and control groups. Secondary outcomes included changes in anxiety symptoms, health-related quality of life, and the presence of psychiatric diagnoses at the sixth week after birth.

Participants completed all baseline questionnaires after delivery in the maternity ward and the follow-up questionnaires online at six weeks postpartum.

Depressive Symptoms. We used the EPDS as a measure of depressive symptomatology; the primary outcome of our trial (Cox et al., 1987). The EPDS is a self-report questionnaire and is the gold standard for identifying women at risk of developing depression in the perinatal period. It is a validated instrument for measuring symptoms of perinatal depression and has recently undergone psychometric validation in the Czech setting (Horáková et al., 2022). The EPDS is a 10-item self-report instrument, with items scored on a 4-point scale, producing a summative score ranging from 0 to 30. Higher scores indicate lower mood. In the present study, the internal consistency (Cronbach’s alpha = .89) was good.

Anxiety Symptoms. This outcome was measured using the Perinatal Anxiety Screening Scale (PASS). The PASS is a self-report questionnaire used to measure anxiety symptoms in the perinatal period, with well-validated psychometric properties; Cronbach’s a = .96 (Somerville et al., 2014). The PASS is a 31-item self-report instrument developed to assess different aspects of perinatal anxiety symptoms. Items are rated on Likert-type scale producing a summative score ranging from 0 to 93 with higher scores indicating greater levels of anxiety symptoms. In the present study, the internal consistency (Cronbach’s alpha = .94) was excellent.

Health-Related Quality of Life. Health-related quality of life was assessed using the Assessment of Quality of Life - Eight Dimension scale (AQoL-8D) (Richardson et al., 2014). This scale covers eight dimensions of quality of life that form two super-dimensions: Physical (independent living, senses, and pain) and Psychosocial (mental health, relationships, coping, self-worth, and happiness). The AQoL-8D provides a utility score ranging from 1.00 (full health) to .00 (death-equivalent health states) (Hawthorne & Osborne, 2005). The AQoL-8D has previously been used in the Czech mental health research within an international context (Nordstroem et al., 2017). In the present study, the internal consistency (Cronbach’s alpha = .95) was excellent.

Presence of Psychiatric Diagnoses. At six weeks postpartum, women were contacted by telephone and administered the Mini-International Neuropsychiatric Interview 5 (MINI5) (Sheehan et al., 1998). The MINI5 is a brief structured diagnostic interview developed to provide a rapid but accurate psychiatric assessment according to the International Classification of Diseases 10 for research purposes as well as part of clinical practice. It takes approximately 15 minutes to administer and it is a widely used and psychometrically validated instrument. The MINI5 was administered by two trained clinical psychiatrists.

Based on previously published studies indicating that the effect of peer support in reducing self-assessed depressive symptoms is moderate (Shorey et al., 2018), we calculated the sample size needed to detect a medium-sized intergroup difference on the Edinburgh Postnatal Depression Scale (effect size = 0.60) with a power of 80% and a significance level of 5% (two-tailed). Thus, with the power analysis set in this way and a potential drop out rate of 30%, the minimum file size required for the intervention part of the study was 120 women (60 for each group).

Using descriptive statistics (means, SDs, or proportions), we calculated the difference between baseline and follow up data as follows for all study outcomes: ΔEPDS = EPDS score at week six – EPDS score at baseline. The distribution of each variable was tested by kurtosis and skewness analysis, using interval -1 to +1 as indicator of approximate normal distribution (Mishra et al., 2019). For categorical data, we used Pearson’s chi-square test to examine differences between the two study groups. Independent two-sample t-tests were conducted for data at the interval level of measurement. We conducted one way ANCOVAs to determine a statistically significant difference between the intervention and the control group on the Δ scores controlling for the baseline scores and age. The statistical significance for all tests was set at p < .05. The standardized effect size for each significant intergroup difference was calculated as Cohen’s d. The reliability of the scales used in our study was estimated using Cronbach’s alpha (Tavakol & Dennick, 2011). The analyses were performed using the SPSS software package, version 23.

The Mom Supports Mom intervention was associated with a decrease in depressive symptomatology at six weeks postpartum, compared to the control group (Cohen’s d = 0.30; 95% CI = 0.10-0.48, p = .003). The effect remained significant after controlling for participants’ baseline depressive symptomatology and age, F(1, 484) = 4.979, p = .026. Further, it was associated with decreased anxiety symptomatology at six weeks postpartum, compared to the control group (Cohen’s d = 0.29; 95% CI = 0.10-0.47, p = .003). The effect also remained significant after controlling for covariates, F(1, 484) = 6.177, p =.013. Finally, the Mom Supports Mom intervention was associated with increased health related quality of life at six weeks postpartum as compared to the control group (Cohen’s d = 0.27; 95% CI = 0.08-0.45, p = .008), and the effect also remained significant after controlling for covariates, F(1, 484) = 7.072, p = .008. However, we found no statistical difference between the groups in the presence of psychiatric diagnoses at the sixth week postpartum. For detailed results, see Table 3 and 4.

Our findings must be interpreted in the context of several limitations. First of all, we must mention the relatively high dropout rate among the study participants. This fact may affect the possible generalization of our result (Bell et al., 2013). The high dropout rate in our study can be explained by several reasons. Firstly, all contact between the research team and participants was remote, via email communication or telephone call, and study participants were not financially or otherwise motivated to complete the follow-up questionnaires or undergo research telephone calls. Finally, recruitment to the study began in 2020, at the beginning of the COVID pandemic, which may have also influenced participants’ willingness to participate in the study (Bagiella et al., 2020). Another limitation is the high number of unrealized peer contacts in the intervention group. Thus, we have an opportunity to improve the delivery process of our intervention before its wider implementation. However, peer contact was initiated with all participants randomized to the intervention group. In the future, we aim to offer the Mom Supports Mom intervention universally in Czech maternity hospitals, but peer contact will only be initiated with women who express an interest. Further, The study design did not involve blinding of participants and peer consultants, as it was clear to the participants which group they belonged to. Only the outcomes raters were blinded. This is a limitation of the study design, given the nature of the intervention (peer support vs. care as usual). In our study, participants were randomly assigned to either the intervention or control group using a computer-generated randomization process, ensuring true randomization. However, allocation to treatment groups was not concealed, as participants were aware of their group assignment based on the intervention they received. While peer consultants knew which participants were assigned to the intervention group (since only this group received peer support), they also provided support to women outside the study. Therefore, they were unsure whether they were providing support to a participant in the study or not, which helps mitigate potential biases in the delivery of support. Both the intervention and control groups received treatment in line with their respective assignments, but aside from the peer support in the intervention group, no other differences were introduced in the treatment approach. We conducted a per-protocol analysis, including only participants who fully adhered to the intervention they were assigned to. Specifically, only participants who received peer support were included in the intervention group analysis. Another limitation of our work is that our peer counsellors did not sufficiently record information about the peer contacts as their main focus was on working with support users. Thus, we lacked information on the length of telephone contacts or detailed information on the support they provided. Therefore, we could not specifically analyse the effect of the amount of support provided, but we analysed all intervened participants in one group. Based on this experience, we recommend future researchers in the field of peer interventions to keep a detailed record of the support sessions that took place.

Peer intervention Mom Supports Mom, which follows up on screening for presence of symptoms of mental disorders after childbirth in maternity hospital, is effective in reducing depressive and anxiety symptomatology in postpartum women. It is also effective in increasing their health-related quality of life. As these effects can already be found at low-frequency peer support, our study has actual public health implications for Czech republic. The Mom Supports Mom can serve as a low intensity approach that is effective for mild illness and has potential to be scalable. Our current treatment approach often involves referring women for therapy and medical treatment; however, Mom Supports Mom offers a way to address mild illness that is both easily accessible and inexpensive. Our results can also help other non-western countries at a similar economic level as the Czech Republic to implement similar approaches.

Peer intervention, following the screening for symptoms of mental disorders in maternity hospital, is effective in reducing depressive and anxiety symptomatology in postpartum women.